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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT2
All Species:
8.79
Human Site:
S199
Identified Species:
16.11
UniProt:
Q8IXJ6
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IXJ6
NP_036369.2
389
43182
S199
T
S
H
C
V
S
A
S
C
R
H
E
Y
P
L
Chimpanzee
Pan troglodytes
XP_001168156
319
35635
C154
V
T
P
K
C
E
D
C
Q
S
L
V
K
P
D
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_855382
347
38546
S182
P
K
C
E
K
C
H
S
V
V
K
P
D
I
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8VDQ8
389
43238
S199
T
S
H
C
V
N
T
S
C
R
K
E
Y
T
M
Rat
Rattus norvegicus
Q5RJQ4
350
39301
E185
S
E
A
T
P
K
C
E
K
C
Q
N
V
V
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001017414
412
44719
S213
T
A
H
C
L
R
S
S
C
R
H
Q
Y
D
L
Frog
Xenopus laevis
NP_001088636
413
45548
F227
S
S
H
C
V
G
A
F
C
G
A
E
Y
S
L
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
L197
T
S
H
C
V
S
F
L
C
R
K
E
Y
S
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650880
355
40094
C190
F
A
D
R
L
P
K
C
Q
K
C
Q
G
V
V
Honey Bee
Apis mellifera
XP_393038
355
40940
T190
K
L
V
E
A
H
G
T
F
H
T
G
R
C
L
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
R265
F
S
K
C
T
C
T
R
C
G
Q
K
Y
D
G
Sea Urchin
Strong. purpuratus
XP_001195952
400
43895
N196
T
G
H
C
L
N
C
N
E
M
Y
T
E
E
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53686
357
39961
F192
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82
N.A.
75.8
N.A.
87.6
78.4
N.A.
N.A.
63.3
63.4
63.5
N.A.
43.7
47.5
25.2
47.2
Protein Similarity:
100
82
N.A.
82.2
N.A.
94.5
84.5
N.A.
N.A.
78.4
76
77.8
N.A.
59.6
61.4
39.8
64.7
P-Site Identity:
100
6.6
N.A.
6.6
N.A.
66.6
0
N.A.
N.A.
60
60
66.6
N.A.
0
6.6
26.6
20
P-Site Similarity:
100
13.3
N.A.
13.3
N.A.
80
6.6
N.A.
N.A.
86.6
66.6
73.3
N.A.
33.3
13.3
33.3
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
33.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
52.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
8
0
8
0
16
0
0
0
8
0
0
0
0
% A
% Cys:
0
0
8
54
8
16
16
16
47
8
8
0
0
8
0
% C
% Asp:
0
0
16
0
0
8
8
0
0
0
0
0
8
16
16
% D
% Glu:
0
16
0
16
0
8
0
8
8
8
0
31
8
8
0
% E
% Phe:
16
0
0
0
0
0
8
16
8
0
0
0
0
0
0
% F
% Gly:
8
8
0
0
0
8
8
0
0
16
0
8
8
0
8
% G
% His:
0
0
47
0
0
8
8
0
0
8
16
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% I
% Lys:
8
8
8
8
8
8
8
0
8
8
24
8
8
0
8
% K
% Leu:
0
8
0
8
24
0
0
8
0
0
8
0
8
0
31
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
16
% M
% Asn:
0
0
0
0
0
16
0
8
0
0
0
8
0
8
0
% N
% Pro:
8
0
8
0
16
8
0
0
0
0
0
8
0
16
0
% P
% Gln:
0
0
0
0
0
0
0
0
16
0
16
16
0
0
0
% Q
% Arg:
0
0
0
8
0
8
0
8
0
31
0
0
8
0
0
% R
% Ser:
16
39
0
0
0
16
16
31
8
8
0
0
0
16
8
% S
% Thr:
39
8
0
8
8
0
16
8
0
0
16
8
0
8
0
% T
% Val:
8
0
8
0
31
0
0
0
8
8
0
8
8
16
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
8
0
47
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _